| PBPKO:06012 |
amount in bile |
The amount of chemical in bile.
|
abile
|
| PBPKO:00283 |
percentile 97.5 cplasma |
A plasma concentration parameter representing the 97.5th percentile of the plasma concentration distribution in a population simulation.
|
|
| PBPKO:06024 |
unbound venous fat concentration |
The unbound venous concentration of compound in the fat compartment.
|
cvfat_unbound
|
| PBPKO:06025 |
unbound venous bone marrow concentration |
The unbound venous concentration of compound in the bone marrow compartment.
|
cvbm_unbound
|
| PBPKO:00300 |
concentration in teeth |
A biological matrix concentration specifically representing the total concentration of compound in the teeth compartment.
|
cteeth
|
| PBPKO:00505 |
amount in bone marrow |
The amount of compound in the bone marrow compartment.
|
abm
|
| PBPKO:00639 |
amount in skin stratum corneum of unexposed skin |
The amount of chemical in skin stratum corneum of unexposed skin
|
askin_sc_u
|
| PBPKO:00253 |
peak concentration |
An output parameter representing the highest concentration (Cmax) of a compound achieved after exposure.
|
Cmax
|
| PBPKO:00623 |
amount in blood |
The amount of compound in the blood compartment.
|
ablood
|
| PBPKO:00550 |
amount in fat |
The amount of compound in the fat compartment.
|
afat
|
| PBPKO:06015 |
amount in intestinal tissue |
The amount of chemical in intestinal tissue
|
ait
|
| PBPKO:00279 |
min organ concentration |
An output parameter representing the minimum concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:06023 |
unbound venous lung concentration |
The unbound venous concentration of compound in the lung compartment.
|
cvlung_unbound
|
| PBPKO:06049 |
concentration in spleen |
The concentration of chemical in spleen compartment.
|
cspleen
|
| PBPKO:06020 |
unbound venous brain concentration |
The unbound venous concentration of compound in the brain compartment.
|
cvbrain_unbound
|
| PBPKO:00438 |
concentration in milk |
The total concentration of compound in the milk compartment.
|
cmilk
|
| PBPKO:06054 |
concentration in medium |
|
|
| PBPKO:00638 |
amount in viable epidermis of exposed skin |
The amount of chemical in viable epidermis of exposed skin
|
askin_e
|
| PBPKO:00547 |
concentration in mammary gland |
The total concentration of compound in the mammary gland compartment.
|
cmam
|
| PBPKO:00263 |
bioavailability |
An output parameter representing the rate and extent to which an active compound is absorbed and becomes available at the site of action or systemic circulation.
|
f
|
| PBPKO:00265 |
mean absorption time |
An output parameter representing the average time for a compound to be absorbed into systemic circulation (MAT).
|
MAT
|
| PBPKO:00541 |
concentration in kidney |
The total concentration of compound in the kidney compartment.
|
ckidney
|
| PBPKO:00543 |
concentration in lung |
The total concentration of compound in the lung compartment.
|
clung
|
| PBPKO:06061 |
concentration in air |
|
|
| PBPKO:06008 |
amount in large intestine |
The amount of chemical in large intestine compartment.
|
ali
|
| PBPKO:06030 |
total venous liver concentration |
The total venous concentration of compound in the liver compartment.
|
cvliver
|
| PBPKO:00633 |
amount in alveolar air |
The amount of compound in the alveolar air compartment.
|
aalveolar
|
| PBPKO:06047 |
concentration in lumen |
The concentration of chemical in lumen of intestine.
|
clumen
|
| PBPKO:06058 |
concentration in microsomes |
|
|
| PBPKO:00277 |
steady state area under curve |
An area under curve parameter calculated over a dosing interval at steady state (AUCss).
|
aucss
|
| PBPKO:00256 |
area under curve |
An output parameter representing the integral of the concentration-time curve (AUC), indicating total exposure.
|
AUC
|
| PBPKO:00538 |
concentration in gut |
The total concentration of compound in the gut compartment.
|
cgut
|
| PBPKO:00640 |
amount in skin stratum corneum of exposed skin |
The amount of chemical in skin stratum corneum of exposed skin
|
askin_sc_e
|
| PBPKO:06048 |
concentration in bile |
The concentration of chemical in bile.
|
cbile
|
| PBPKO:00058 |
amount of metabolized |
An output parameter representing the total amount of compound metabolized.
|
ametab
|
| PBPKO:00272 |
amount in urine |
The amount of compound in the urine compartment.
|
aurine
|
| PBPKO:00500 |
amount in delay |
The amount of compound in the hypothetical delay compartment.
|
adelay
|
| PBPKO:06006 |
amount in jejunum |
The amount of chemical in jejunum compartment.
|
aj
|
| PBPKO:00273 |
amount in feces |
The amount of compound in the feces compartment.
|
afeces
|
| PBPKO:06055 |
concentration in cell |
|
|
| PBPKO:00257 |
area under curve 0 to t |
An area under curve parameter calculated from time zero to a specific time point t (AUC0-t).
|
auc 0 to t
|
| PBPKO:00540 |
concentration in brain |
The total concentration of compound in the brain compartment.
|
cbrain
|
| PBPKO:06035 |
total venous lung concentration |
The total venous concentration of compound in the lung compartment.
|
cvlung
|
| PBPKO:06031 |
total venous gut concentration |
The total venous concentration of compound in the gut compartment.
|
cvgut
|
| PBPKO:06051 |
amount in skin surface depot |
An amount of compound in compartment representing the mass of chemical on the skin surface.
|
|
| PBPKO:00504 |
amount in lung |
The amount of compound in the lung compartment.
|
alung
|
| PBPKO:00299 |
concentration in nail |
A biological matrix concentration specifically representing the total concentration of compound in the nail compartment.
|
cnail
|
| PBPKO:00503 |
amount in brain |
The amount of compound in the brain compartment.
|
abrain
|
| PBPKO:00254 |
maximum steady state concentration |
An output parameter representing the maximum concentration (Cmax,ss) achieved at steady state during repeated dosing.
|
cmaxss
|
| PBPKO:00255 |
maximum time |
An output parameter representing the time (Tmax) required to reach the peak concentration.
|
tmax
|
| PBPKO:06042 |
concentration in small intestine |
The concentration of chemical in small intestine compartment.
|
csi
|
| PBPKO:00259 |
area under curve 0 to infinity |
An area under curve parameter extrapolated from time zero to infinity (AUC0-inf), representing total exposure after a single dose.
|
auc 0 infinity
|
| PBPKO:06052 |
maximum amount |
The maximum amount of chemical in a compartment
|
amax
|
| PBPKO:06009 |
amount in lumen |
The amount of chemical in lumen of the intestine.
|
alumen
|
| PBPKO:06018 |
unbound venous liver concentration |
The unbound venous concentration of compound in the liver compartment.
|
cvliver_unbound
|
| PBPKO:00506 |
amount in skin |
The amount of compound in the skin compartment.
|
askin
|
| PBPKO:06005 |
amount in small intestine |
The amount of chemical in small intestine compartment
|
asi
|
| PBPKO:00546 |
concentration in skin |
The total concentration of compound in the skin compartment.
|
cksin
|
| PBPKO:00281 |
median organ concentration |
An output parameter representing the median concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:06060 |
concentration in polymer |
|
|
| PBPKO:06022 |
unbound venous filtrate concentration |
The unbound venous concentration of compound in the filtrate compartment.
|
cvfiltrate_unbound
|
| PBPKO:06004 |
amount in stomach |
The amount of chemical in stomach compartment.
|
asto
|
| PBPKO:06027 |
unbound venous mammary gland concentration |
The unbound venous concentration of compound in the mammary gland compartment.
|
cvmam_unbound
|
| PBPKO:06028 |
unbound venous rest body concentration |
The unbound venous concentration of compound in the rest body compartment.
|
cvrestbody_unbound
|
| PBPKO:06003 |
unbound concentration of compund in compartment |
|
|
| PBPKO:06044 |
concentration in ileum |
The concentration of chemical in ileum compartment.
|
ci
|
| PBPKO:00632 |
amount in venous blood |
The amount of compound in the venous blood compartment.
|
avenousblood
|
| PBPKO:06057 |
concentration in lysosomes |
|
|
| PBPKO:00544 |
concentration in fat |
The total concentration of compound in the fat compartment.
|
cfat
|
| PBPKO:06014 |
amount in duodenum |
The amount of chemical in duodenum compartment.
|
aduo
|
| PBPKO:06036 |
total venous fat concentration |
The total venous concentration of compound in the fat compartment.
|
cvfat
|
| PBPKO:06026 |
unbound venous skin concentration |
The unbound venous concentration of compound in the skin compartment.
|
cvksin_unbound
|
| PBPKO:00274 |
cumulative amount in urine |
An output parameter representing the total amount of compound excreted in urine over a specific time period.
|
|
| PBPKO:00297 |
biological matrix concentration |
An output parameter representing the total concentration of a compound in a specified biological matrix.
|
|
| PBPKO:00261 |
mean residence time |
An output parameter representing the average time a compound resides in the body (MRT).
|
MRT
|
| PBPKO:00264 |
relative bioavailability |
A bioavailability parameter comparing the rate and extent of absorption of a test compound to a reference compound.
|
frel
|
| PBPKO:00275 |
cumulative amount in feces |
An output parameter representing the total amount of compound excreted in feces over a specific time period.
|
|
| PBPKO:00629 |
amount in richly perfused tissue |
The amount of compound in the richly perfused tissue compartment.
|
arichlyperfused
|
| PBPKO:00616 |
concentration of compound in compartment |
An output parameter representing the total concentration of compound in the compartment.
|
|
| PBPKO:06059 |
concentration in intracellular water |
|
|
| PBPKO:00637 |
amount in viable epidermis of unexposed skin |
The amount of chemical in viable epidermis of unexposed skin
|
askin_u
|
| PBPKO:06037 |
total venous bone marrow concentration |
The total venous concentration of compound in the bone marrow compartment.
|
cvbm
|
| PBPKO:00289 |
reference dose |
An output parameter (or exposure limit) estimating the daily oral or dermal exposure likely to be without appreciable risk over a lifetime (RfD).
|
RfD
|
| PBPKO:06019 |
unbound venous gut concentration |
The unbound venous concentration of compound in the gut compartment.
|
cvgut_unbound
|
| PBPKO:00630 |
amount in poorly perfused tissue |
The amount of compound in the poorly perfused tissue compartment.
|
apoorlyperfused
|
| PBPKO:00548 |
concentration in restbody |
The total concentration of compound in the rest of body compartment.
|
crestbody
|
| PBPKO:06039 |
total venous mammary gland concentration |
The total venous concentration of compound in the mammary gland compartment.
|
cvmam
|
| PBPKO:06050 |
concentration in feces |
The concentration of chemical in feces.
|
cfeces
|
| PBPKO:06053 |
amount in follicles |
An amount of compound in compartment representing the mass of chemical within the hair follicles.
|
|
| PBPKO:06056 |
concentration in mitochondria |
|
|
| PBPKO:06007 |
amount in ileum |
The amount of chemical in ileum compartment.
|
ai
|
| PBPKO:06010 |
amount in small intestine segment |
The amount of chemical in segment of small intestine.
|
asi_segment
|
| PBPKO:06017 |
unbound concentration in plasma |
The unbound concentration of compound in the plasma compartment.
|
cplasma_unbound
|
| PBPKO:00631 |
amount in arterial blood |
The amount of compound in the arterial blood compartment.
|
aarterialblood
|
| PBPKO:06011 |
amount in colon |
The amount of chemical in colon compartment.
|
acolon
|
| PBPKO:00290 |
acceptable daily intake |
An output parameter (or exposure limit) estimating the amount of a substance in food/water that can be consumed daily without appreciable health risk (ADI).
|
adi
|
| PBPKO:00499 |
amount in filtrate |
The amount of compound in the filtrate compartment.
|
afiltrate
|
| PBPKO:06038 |
total venous skin concentration |
The total venous concentration of compound in the skin compartment.
|
cvksin
|
| PBPKO:00285 |
reconstructed exposure |
An output parameter estimating the amount of compound exposure based on internal body measurements.
|
|
| PBPKO:00286 |
estimated daily intake |
An output parameter estimating the amount of a compound consumed daily (EDI).
|
edi
|
| PBPKO:00507 |
amount in mammary gland |
The amount of compound in the mammary gland compartment.
|
amam
|
| PBPKO:00615 |
amount of compound in compartment |
An output parameter representing the amount of chemical specifically in the compartment
|
|
| PBPKO:06041 |
concentration in stomach |
The concentration of chemical in stomach compartment.
|
csto
|
| PBPKO:06040 |
total venous rest body concentration |
The total venous concentration of compound in the rest of the body compartment.
|
cvrestbody
|
| PBPKO:00280 |
max organ concentration |
An output parameter representing the maximum concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:00545 |
concentration in bone marrow |
The total concentration of compound in the bone marrow compartment.
|
cbm
|
| PBPKO:00498 |
amount in kidney |
The amount of compound in the kidney compartment.
|
akidney
|
| PBPKO:00262 |
half-life |
An output parameter representing the time required for the compound concentration to decrease by half (t1/2).
|
t1/2
|
| PBPKO:00282 |
percentile 2.5 cplasma |
A plasma concentration parameter representing the 2.5th percentile of the plasma concentration distribution in a population simulation.
|
|
| PBPKO:00549 |
concentration in plasma |
The total concentration of compound in the plasma compartment.
|
cplasma, cplasma_total
|
| PBPKO:06045 |
concentration in large intestine |
The concentration of chemical in large intestine compartment.
|
cli
|
| PBPKO:06029 |
total venous concentration of compound in compartment |
|
|
| PBPKO:06034 |
total venous filtrate concentration |
The total venous concentration of compound in the filtrate compartment.
|
cvfiltrate
|
| PBPKO:00258 |
area under curve last |
An area under curve parameter calculated from time zero to the time of the last measurable concentration (AUClast).
|
auclast
|
| PBPKO:00260 |
area under moment curve |
An output parameter calculated as the integral of the product of time and concentration versus time (AUMC).
|
aumc
|
| PBPKO:06043 |
concentration in jejunum |
The concentration of chemical in jejunum compartment.
|
cj
|
| PBPKO:06002 |
unbound venous concentration of compound in compartment |
|
|
| PBPKO:00497 |
amount in liver |
The amount of compound in the liver compartment.
|
aliver
|
| PBPKO:00267 |
bioequivalence |
An output parameter indicating comparable bioavailability between test and reference formulations under similar conditions.
|
be
|
| PBPKO:06033 |
total venous brain concentration |
The total venous concentration of compound in the brain compartment.
|
cvbrain
|
| PBPKO:00266 |
mean dissolution time |
An output parameter representing the average time for a compound to dissolve in the body (MDT).
|
MDT
|
| PBPKO:06016 |
amount in portal vein |
The amount of chemical in portal vein.
|
apv
|
| PBPKO:00502 |
amount in plasma |
The amount of compound in the plasma compartment.
|
aplasma
|
| PBPKO:00302 |
concentration in urine |
A biological matrix concentration specifically representing the total concentration of compound in the urine compartment.
|
curine
|
| PBPKO:00252 |
output parameter |
A parameter representing a result or prediction generated by the PBPK model.
|
|
| PBPKO:00287 |
biomonitoring equivalent |
An output parameter representing the concentration of a chemical (or metabolite) in a biological medium consistent with exposure guidance values (BE).
|
be
|
| PBPKO:06021 |
unbound venous kidney concentration |
The unbound venous concentration of compound in the kidney compartment.
|
cvkidney_unbound
|
| PBPKO:00298 |
concentration in hair |
The total concentration of compound in the hair compartment.
|
chair
|
| PBPKO:06046 |
concentration in intestinal tissue |
The concentration of chemical in tissue of intestine.
|
cit
|
| PBPKO:00539 |
concentration in liver |
The total concentration of compound in the liver compartment.
|
cliver
|
| PBPKO:00284 |
tolerable daily intake |
An output parameter (or exposure limit) estimating the amount of a substance that can be ingested daily over a lifetime without appreciable health risk (TDI).
|
tdi
|
| PBPKO:00301 |
concentration in blood |
The total concentration of compound in the blood compartment.
|
cblood
|
| PBPKO:00542 |
concentration in filtrate |
The total concentration of compound in the filtrate compartment.
|
cfiltrate
|
| PBPKO:00496 |
amount in gut |
The amount of compound in the gut compartment.
|
agut
|
| PBPKO:06013 |
amount in spleen |
The amount of chemical in spleen compartment
|
aspleen
|
| PBPKO:06032 |
total venous kidney concentration |
The total venous concentration of compound in the kidney compartment.
|
cvkidney
|
| PBPKO:00268 |
absolute bioavailability |
A bioavailability parameter comparing the amount reaching systemic circulation after non-IV administration to the amount available after IV administration.
|
fabs
|
| PBPKO:00501 |
amount in restbody |
The amount of compound in the rest of the body compartment.
|
arestbody
|